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{"id":1583,"date":"2022-11-03T19:48:53","date_gmt":"2022-11-04T02:48:53","guid":{"rendered":"https:\/\/professorming.net\/?p=1583"},"modified":"2022-11-03T19:48:55","modified_gmt":"2022-11-04T02:48:55","slug":"%e7%9b%9f%e5%a7%94%e5%93%a1%e6%9c%83%e9%a6%96%e6%89%b9%e5%80%99%e9%81%b8%e4%ba%94%e7%a8%ae%e6%b2%bb%e7%99%82covid-19%e6%9c%89%e6%95%88%e8%97%a5%e7%89%a9%e7%b5%84%e5%90%88","status":"publish","type":"post","link":"https:\/\/professorming.net\/2022\/11\/03\/1583","title":{"rendered":"\u76df\u59d4\u54e1\u6703\u9996\u6279\u5019\u9078\u4e94\u7a2e\u6cbb\u7642COVID-19\u6709\u6548\u85e5\u7269\u7d44\u5408"},"content":{"rendered":"\n

\u95dc\u65bc\u6b50\u76df\u59d4\u54e1\u6703\u9996\u6279\u5019\u9078\u4e94\u7a2e\u6709\u6548\u85e5\u7269\u7d44\u5408:
\u7531\u65bc COVID-19 \u75be\u75c5\u7684\u8907\u96dc\u6027\uff0c\u6b63\u5728\u958b\u767c\u591a\u7a2e\u85e5\u7269\uff0c\u4f8b\u5982\u6297\u75c5\u6bd2\u85e5\u3001\u514d\u75ab\u8abf\u7bc0\u5291\u3001\u6297\u708e\u85e5\u3002\u5019\u9078\u85e5\u7269\u5305\u62ec\u5c0f\u5206\u5b50\u3001\u55ae\u514b\u9686\u6297\u9ad4\u4ee5\u53ca\u57fa\u65bc\u7d30\u80de\u7684\u7642\u6cd5\u3002
\u6b63\u5728\u9032\u884c\u7684\u81e8\u5e8a\u8a66\u9a57\u8457\u773c\u65bc\u6b63\u5728\u958b\u767c\u7684\u7522\u54c1\u5728\u4e0d\u540c\u75be\u75c5\u968e\u6bb5\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff1a\u4f8b\u5982\u65e9\u671f\u3001\u8f15\u5ea6\u3001\u4e2d\u5ea6\u3001\u91cd\u5ea6 COVID-19 \u75be\u75c5\uff1b\u5728\u4e0d\u540c\u7684\u60a3\u8005\u4e9e\u7fa4\u4e2d\uff1a\u9580\u8a3a\u548c\u4f4f\u9662\u60a3\u8005\uff1b\u66b4\u9732\u65bc\u611f\u67d3\u7684\u4eba\u548c\u9577\u671f\u7684 COVID \u60a3\u8005\u3002<\/p>\n\n\n\n

\u4e94\u7a2e\u85e5\u7269\u7684\u5176\u4e2d\u56db\u7a2e\u7642\u6cd5\u662f\u7531\u6b50\u6d32\u85e5\u54c1\u7ba1\u7406\u5c40\u6301\u7e8c\u8a55\u4f30\u7684”\u55ae\u514b\u9686\u6297\u9ad4”:\u3002
\u76ee\u524d EMA \u6b63\u5728\u6efe\u52d5\u5be9\u67e5\u7684\u56db\u7a2e\u7642\u6cd5\u662f\u6297\u75c5\u6bd2\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u5b83\u5011\u91dd\u5c0d\u5c0e\u81f4 COVID-19 \u7684 SARS-CoV-2 \u75c5\u6bd2\u8868\u9762\u7684\u4e00\u7a2e\u86cb\u767d\u8cea\uff08\u5c16\u5cf0\u86cb\u767d\uff09\uff0c\u9632\u6b62\u75c5\u6bd2\u9032\u5165\u4eba\u9ad4\u7d30\u80de\u3002\u5c07\u5b83\u5011\u7d0d\u5165\u6efe\u52d5\u5be9\u67e5\u7a0b\u5e8f\u662f\u57fa\u65bc\u81e8\u5e8a\u7814\u7a76\u7684\u6709\u5e0c\u671b\u7684\u521d\u6b65\u7d50\u679c\u3002
\u7b2c\u4e94\u7a2e\u662f\u7372\u5f97\u4e0a\u5e02\u8a31\u53ef\u7684\u514d\u75ab\u6291\u88fd\u5291\uff0c\u53ef\u4ee5\u64f4\u5c55\u5230\u6cbb\u7642 COVID-19 \u60a3\u8005\u3002\u8207\u55ae\u514b\u9686\u6297\u9ad4\u4e0d\u540c\u7684\u662f:Baricitinib(\u5df4\u745e\u66ff\u5c3c)\u662f\u4e00\u7a2e\u514d\u75ab\u6291\u88fd\u5291\uff08\u4e00\u7a2e\u964d\u4f4e\u514d\u75ab\u7cfb\u7d71\u6d3b\u6027\u7684\u85e5\u7269\uff09\uff0c\u76ee\u524d\u88ab\u6388\u6b0a\u7528\u65bc\u60a3\u6709\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u985e\u98a8\u6fd5\u6027\u95dc\u7bc0\u708e\u6216\u7279\u61c9\u6027\u76ae\u708e\u7684\u6210\u4eba\u3002<\/p>\n\n\n\n

\u65b0\u4e94\u7a2e\u6cbb\u7642\u65b0\u51a0\u72c0\u75c5\u6bd2\u7684\u85e5\u7269\u4ecb\u7d39:<\/p>\n\n\n\n

1\u3002Bamlanivimab \u548c Etesevimab \u7d44\u5408:<\/strong>
\u662f\u65b0\u51a0\u75c5\u6bd2\u55ae\u514b\u9686\u6297\u9ad4\u7684\u96d9\u6297\u7d44\u5408\uff0c\u53ef\u964d\u4f4e\u4f4f\u9662\u548c\u6b7b\u4ea1\u98a8\u96aa70%\u3002 https:\/\/m.21jingji.com\/article\/20210210\/herald\/bf3e98a73c06604b18f4933bd927e5b2.html<\/a><\/p>\n\n\n\n

FDA \u64f4\u5927\u4e86\u5c0d AbCelera \u767c\u73fe\u7684 Bamlanivimab \u8207 Etesevimab \u806f\u5408\u7d66\u85e5\u7684\u7dca\u6025\u4f7f\u7528\u6388\u6b0a\uff0c\u4ee5\u5305\u62ec\u9810\u9632 COVID-19 \u7684\u66b4\u9732\u5f8c\u9810\u9632\u3002
https:\/\/investors.abcellera.com\/news\/news-releases\/2021\/Emergency-Use-Authorization-of-AbCellera-Discovered-Bamlanivimab-Administered-with-Etesevimab-Expanded-by-the-FDA-to-Include-Post-Exposure-Prophylaxis-for-the-Prevention-of-COVID-19\/default.aspx<\/a><\/p>\n\n\n\n

\u5305\u542b\u6210\u4eba\u548c\u5152\u7ae5\u60a3\u8005\uff0812\u6b72\uff09\u63a5\u89f8\u5f8c\u9810\u9632\uff0c\u4ee5\u53ca\u8001\u5e74\u4eba\uff08\u9ad4\u91cd\u81f3\u5c1140\u516c\u65a4\uff09\u60a3\u56b4\u91cd\u51a0\u72c0\u75c5\u6bd2\u3002https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-authorizes-bamlanivimab-and-etesevimab-monoclonal-antibody-therapy-post-exposure-prophylaxis<\/a><\/p>\n\n\n\n

2\u3002Ronapreve:<\/strong>
\u8a72\u85e5\u7269\u70ba\u65b0\u51a0\u72c0\u75c5\u6bd2\u55ae\u514b\u9686\u6297\u9ad4\u7d44\u5408\u7522\u54c1\u3002\u53ef\u7528\u65bc\u9810\u9632\u611f\u67d3\u3001\u6cbb\u7642\u56b4\u91cd\u611f\u67d3\u7684\u75c7\u72c0\u4e26\u964d\u4f4e\u5165\u9662\u7684\u53ef\u80fd\u6027\u3002
https:\/\/www.dailymail.co.uk\/news\/article-10002533\/amp\/Life-saving-antibody-cocktail-given-Donald-Trump-given-vulnerable-NHS-patients.html?__twitter_impression=true<\/a>
\u91dd\u5c0d\u7121\u6cd5\u5efa\u7acb\u6297\u9ad4\u53cd\u61c9\u7684\u82f1\u570b\u201c\u6700\u8106\u5f31\u201d\u4f4f\u9662\u60a3\u8005\u5c07\u7372\u5f97\u4e00\u7a2e\u65b0\u85e5 Ronapreve\u5b83\u5df2\u88ab\u8b49\u660e\u53ef\u4ee5\u5c07\u4f4f\u9662\u6642\u9593\u7e2e\u77ed 4 \u5929\u4e26\u5c07\u6b7b\u4ea1\u98a8\u96aa\u964d\u4f4e\u4e94\u5206\u4e4b\u4e00\u3002
https:\/\/www.bbc.co.uk\/news\/health-58602999.amp<\/a>
\u6578\u4ee5\u5343\u8a08\u7684\u60a3\u8005\u5c07\u5f9e\u633d\u6551\u751f\u547d\u7684\u65b0 
#COVID19<\/a> \u6cbb\u7642\u4e2d\u53d7\u76ca\u3002https:\/\/www.gov.uk\/government\/news\/thousands-of-patients-to-benefit-from-life-saving-covid-19-treatment<\/a><\/p>\n\n\n\n

3\u3002Regdanvimab:<\/strong>
\u91dd\u5c0dCOVID-19 \u55ae\u514b\u9686\u6297\u9ad4\u6cbb\u7642\u85e5\u7269 regdanvimab (CT-P59) \u6210\u70ba\u97d3\u570b\u98df\u54c1\u85e5\u54c1\u5b89\u5168\u90e8 (MFDS\u200b\u200b) \u6279\u51c6\u7684\u9996\u500b COVID-19 \u6388\u6b0a\u6cbb\u7642 \u3002
https:\/\/amp.theguardian.com\/world\/2021\/sep\/18\/covid-antibody-drug-ronapreve-to-be-given-to-vulnerable-nhs-patients?utm_term=Autofeed&CMP=twt_gu&utm_medium=&utm_source=Twitter&__twitter_impression=true<\/a><\/p>\n\n\n\n

4\u3002sotrovimab:<\/strong>
\u662f\u4e00\u7a2e\u55ae\u514b\u9686\u6297\u9ad4\u7642\u6cd5\uff0c\u9019\u7a2e\u85e5\u7269\u5df2\u7d93\u7528\u65bc\u6cbb\u7642\u764c\u75c7\u548c\u95dc\u7bc0\u708e\u3002
\u4f86\u81ea\u963f\u806f\u914b 6,175 \u540d Covid-19 \u60a3\u8005\u7684\u6578\u64da\u986f\u793a\uff0c\u4e00\u7a2e\u65b0\u7684\u6297\u75c5\u6bd2\u85e5\u7269 Sotrovimab \u4f3c\u4e4e\u53ef\u4ee5 100% \u6210\u529f\u963b\u6b62\u8a72\u75c5\u6bd2\u5c0e\u81f4\u7684\u6b7b\u4ea1\uff0c\u4e26\u4e14\u53ef\u4ee5 99% \u6709\u6548\u5730\u9632\u6b62\u9032\u5165\u91cd\u75c7\u76e3\u8b77\u5ba4\u3002\u5c24\u5176\u4ee4\u4eba\u6b23\u6170\u7684\u662f\uff0c\u8d85\u904e\u4e00\u534a\u7684\u53d7\u52a9\u8005\u5e74\u9f61\u5728 50 \u6b72\u4ee5\u4e0a\uff0c\u800c\u4e14\u5e7e\u4e4e\u6240\u6709\u4eba\u90fd\u6709\u4f34\u96a8\u7684\u91ab\u7642\u554f\u984c\uff0c\u4f8b\u5982\u764c\u75c7\u3001\u5fc3\u9ad2\u75c5\u6216\u7cd6\u5c3f\u75c5\u3002
https:\/\/www.thenationalnews.com\/opinion\/editorial\/2021\/07\/19\/new-drugs-are-beating-covid-19-not-just-vaccines\/?outputType=amp&__twitter_impression=true<\/a>
\u88ab\u611f\u67d3\u4e26\u6709\u4f4f\u9662\u98a8\u96aa\u7684\u6fb3\u5927\u5229\u4e9e\u4eba\u73fe\u5728\u53ef\u4ee5\u4f7f\u7528\u65b0\u85e5\u4f86\u9632\u6b62\u75c7\u72c0\u60e1\u5316\uff0c\u81e8\u6642\u6279\u51c6\u4f7f\u7528\u6297\u9ad4\u6cbb\u7642\u85e5Sotrovimab\u3002
https:\/\/amp.news.com.au\/lifestyle\/health\/tga-approves-new-antibody-drug-to-reduce-covid19-hospitalisations\/news-story\/96021d59bce68caf0f27c84f4eba51d7<\/a><\/p>\n\n\n\n

5\u3002Baricitinib :<\/strong>
\u4e00\u7a2e\u514d\u75ab\u6291\u88fd\u5291\uff0c\u964d\u4f4e\u514d\u75ab\u7cfb\u7d71\u6d3b\u6027\u7684\u85e5\u7269\u3002
\u5927\u591a\u6578\u75c5\u6bd2\u90fd\u5df2\u958b\u767c\u51fa\u901a\u904e\u963b\u65b7\u5176\u4fe1\u865f\u50b3\u5c0e\u9014\u5f91\u4f86\u62b5\u6d88\u5e72\u64fe\u7d20\u4f5c\u7528\u7684\u7b56\u7565\uff0c\u62ee\u6297JAK\u2013STAT\u9014\u5f91\u7684\u75c5\u6bd2\u7de8\u78bc\u56e0\u5b50\u662f\u6c7a\u5b9a\u6bd2\u6027\u7684\u95dc\u9375\u56e0\u7d20\u3002
\u5df4\u745e\u66ff\u5c3cBaricitinib\uff08\u9078\u64c7\u6027\u7684JAK1\u548cJAK2\u6291\u88fd\u5291\uff09\u963b\u65b7JAK-STAT\u4fe1\u865f\u6703\u7522\u751f\u5e72\u64fe\u7d20\u4ecb\u5c0e\u7684\u6297\u75c5\u6bd2\u53cd\u61c9\u7684\u640d\u5bb3\uff0c\u4e26\u53ef\u80fd\u5c0dSARS-CoV-2\u611f\u67d3\u7684\u767c\u5c55\u7522\u751f\u6f5b\u5728\u7684\u4fc3\u9032\u4f5c\u7528\u3002
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https:\/\/www.thelancet.com\/journals\/laninf\/article\/PIIS1473-3099(20)30262-0\/fulltext#.XoqGLwkgkck.twitter<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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